Quote: Cell Factory

first_imgFrom CalTech Engineering & Science (LXIX:2, August 2006), “Cellular CAT Scans” by Douglas L. Smith, an article about electron cryotomography imaging of cellular components.  Smith does not mention evolution.  His opening paragraph is reminiscent of Darwin’s Black Box:A cell isn’t merely a bag of enzymes sloshing around in a thick soup of cytoplasm.  According to Assistant Professor of Biology Grant Jensen, it’s more like a multistory factory—a set of interwoven production lines complete with conveyor belts, forklifts, and steel I-beams to hold up the roof.  Or, if you prefer, the world’s most elaborate Rube Goldberg contraption.  The cell’s cogs and camshafts, springs and motors, girders and sheet metal (or, in the Rube Goldberg case, gloved hands on sticks, precariously balanced bathtubs, and spring-loaded mallets) are protein molecules.  Protein machines conduct the cell’s metabolic business; protein motors make muscles contract, amoebas crawl, and paramecia swim.  When a cell is preparing to divide, protein diazo machines make a duplicate set of the genetic blueprints, and then protein winches and cables pull the two copies to opposite ends of the cell.  Shells of interlocking proteins armor-plate viruses, protein trusswork gives cells their shape, and protein stickers on the protein girders tell the cell which end is front.  Jensen’s research group wants to photograph each rod, flywheel, and bearing and work out its mechanical interactions with its fellows, in terms as solid as a cast titanium sprocket.  As Jensen puts it, “Ultimately, of course, we want to understand how things work at an atomic level—a proton goes here and it causes this atom to move over there, which causes that atom to move over here, and the sum of it all is that the cell swims, or eats, or reproduces itself.”(Visited 5 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Taipei Beimen Post Office / 臺北北門郵局 — Geocache of the Week

first_imgDifficulty:1Terrain:1.5 Location:Taipei, TaiwanN 25° 02.820 E 121° 30.668 Letterbox HybridGC3NXZVby kakoui Neither snow nor rain nor heat nor gloom can keep geocachers away from this Letterbox Hybrid. Well, that’s not completely true since this cache is only accessible during business hours, but you catch the drift.The posted coordinates take you just outside the Taipei Beimen Post Office. There, you must locate a small film canister with a key inside. Take that very special key, head inside the post office, and locate mailbox 59535. Inside you will find a manila envelope filled with a logbook, letterbox stamp, SWAG, and hopefully more than a few trackables.Since this is a Letterbox Hybrid, geocachers have a few options after signing the log: use the enclosed stamp in your personal letterboxing logbook, add your personal stamp to the logbook, or lick n’ stick a postage stamp to add to the theme.The post office was originally a modest wooden structure, but in 1913 the building burned down in a fire. Thus, the post office was rebuilt and expanded with construction finishing in April of 1930. The post office is still open and fully functional, complete with stations to mail packages, P.O. boxes, and a geocache.Extra bonus: the North Gate of Old Taipei City is right across the street. The post office and the North Gate are both national historic sites. This Geocache of the Week may get lots of fan mail!Taipei Beimen Post Office exteriorFind the keyHead insideMailbox 59535A well-stocked geocacheSign the logbook and add to the Letterbox experienceHistoric North Gate is just outsideContinue to explore some of the most amazing geocaches around the world.Check out all of the Geocaches of the Week on the Geocaching blog. If you would like to nominate a Geocache of the Week, fill out this form.Share with your Friends:More SharePrint RelatedTop 10 Geocaches of the Week 2017December 27, 2017In “Geocache of the Week”Selfie Letterbox — Geocache of the WeekMay 23, 2018In “Community”Underground — Geocache of the WeekFebruary 7, 2018In “Community”last_img read more

XBRL: Accounting Geeks Get Radical

first_imgbernard lunn Tags:#Analysis#enterprise#NYT#Trends 3 Areas of Your Business that Need Tech Now Related Posts It is not often that something as deeply geeky as XBRL gets onto the front page of Wired magazine. Daniel Roth’s superb article about radical transparency raised the profile of those four letters. What could be more boring than an XML standard for accountants that has been around for a decade? On the other hand, what could be more exciting than something that might disrupt and recreate the deeply broken global financial system? I spent two days at the XBRL US National Conference in New York to find out the reality, which is somewhere in between.The Ultra-Fast XBRL 101For XBRL newbies, here are a few key facts and some links for further research:XBRL stands for eXtensible Business Reporting Language.It is an open standard based on XML, created by an accountant named Charlie Hoffman. Read some quick facts here.If you tag something consistently, software applications can more easily analyze the data and present more useful information. Yes, that sounds like the semantic Web, and we all know that has faced the chicken-and-egg problem (i.e. not enough content is semantically tagged yet). But imagine a semantic Web standard for which governments around the world tell companies that they have to tag data that way.XBRL gained attention in the US when the SEC mandated that public companies report their financial results in XBRL (starting with companies that have a market cap over $5 billion). That has been going on for two quarters now, so all parties are getting real-world experience with XBRL.But XBRL traction is greater in other countries, especially Japan, Australia and Holland, where it is being used to standardize and simplify reporting to government regulators. In the UK, companies report to the taxman using XBRL.The Twitter hash tag is – you guessed it – #xbrl.Why XBRL May Be RevolutionaryThe best analogy for XBRL is the barcode in the retail world. The analogy works because it may take a while to happen… but when it does happen, everything will change. Imagine every number with a standardized tag telling a computer what it is.Here are the revolutionary implications of XBRL:A year ago, the global financial system suffered a cardiac arrest.That scared a lot of people. The patient now walks around the hospital grounds and occasionally forces a healthy smile. But most close observers recognize that the patient is far from healthy and is still indulging in cigarettes and double cheeseburgers. This heart attack affects us all. Radical transparency, to shine a light on those toxic assets and murky financial pools, is the best long-term cure. And XBRL, along with political will, is key to that radical transparency.Ordinary investors don’t trust the stock market.It feels like a casino where the roulette wheel is fixed. That is bad for all players in the economy. We need people to trust numbers again and to invest patiently in great companies that grow and pay for their kids’ tuition and their own retirement. That patient investment will help great companies grow and help those companies create good jobs. That is the way the stock market is supposed to work, and a few idealists think it could work that way in the future. Jane Q. Public needs access to analytical tools that are currently reserved for Wall Street insiders, and she has to have confidence in the numbers. Private investors need to be served by truly independent analysts who charge transparently. XBRL can play an important role in that.The cost for a company to report to government regulators is ridiculously high.This is a hidden tax on jobs (except for accountants!). The time and money spent on this could be used more productively. What if government agencies agreed on a single way to file reports using XBRL? This is happening today in Australia and the Netherlands.There is a major disconnect between the three types of reporting (i.e. to investors, to regulators and to internal management).The third type is what really drives business. These are the “business intelligence” and MIS tools and dashboards that managers rely on to help them run the business. What if one set of numbers could drive all three types of reports auto-magically? We are a long way from this, but the vendors leading the XBRL charge are creating the platforms that will enable this in the future.Today’s Reality CheckThe New York conference was about XBRL in the US, so we will keep the current analysis to what is happening here.The basic reality is that large public companies are obeying the SEC’s mandate by reporting in XBRL. No surprise there: they have to do it.So, they are spending some money to prepare these XBRL-compliant reports, by purchasing vendor tools and outsourcing the work. Some are doing it enthusiastically, anticipating the many downstream benefits. Others are doing it just to check off the box. This is hardly the best year for a new cost with an uncertain ROI. The same bean counters who are asking everyone to cut costs are asking for bigger budgets… “To do what, exactly?”That’s the problem. The returns are very unclear, and they are certainly more than a couple of quarters away, and most managers are thinking pretty short-term these days.The returns are unclear because investors are not using XBRL data in any meaningful way yet. It’s a chicken-and-egg problem. Not enough XBRL data exists yet for serious analysis.Many markets have chicken-and-egg problems. This particular one is easier to forecast because – without stretching the analogy too far – the government (via the SEC) is ordering the chickens to lay eggs.What the Future Will Likely BringThe future is always uncertain, but in this case we can predict a few things with some degree of certainty:More companies will report their financial data using XBRL, because they have to. So, vendors will find ways to make this increasingly easy and low-cost.XBRL will be used in the Mortgage-Backed Securities (MBS) market, because this is the market where we, via the government, own a lot of toxic assets. The technology to do this is available, and the politics indicate that it will happen.XBRL will be used in the bonds market to enable new forms of credit rating, because the current credit rating agencies clearly failed at their job, and the government will want to do something about this.What Is Still Very UnclearWhat new mechanisms, vendors, tools and services will emerge to make this data useful for investors, both individual and institutional?How will this impact the fast-growing $8.8 billion market for business intelligence systems.What will happen when the US government makes a bigger push for transparency using XBRL as leverage? The SEC’s mandate is a great start. But other countries are ahead of the US in XBRL adoption, and the Obama administration is making a big push for data transparency via data.gov and other initiatives. So, we are likely to see more in this area, but precisely what will happen is unclear.center_img Cognitive Automation is the Immediate Future of… IT + Project Management: A Love Affair Massive Non-Desk Workforce is an Opportunity fo…last_img read more

Manchester City owner wants to invest in Malaysian club

first_imgView comments ‘Rebel attack’ no cause for concern-PNP, AFP Duterte wants probe of SEA Games mess Cayetano: Senate, Drilon to be blamed for SEA Games mess Private companies step in to help SEA Games hosting He said that no specific side was discussed.But Syed Saddiq said CFG would be meeting with some presidents of local clubs soon, and he wanted them to make Malaysia “their base in Southeast Asia”.Malaysia’s main divisions are the top-flight super league and the second-tier premier league.At Thursday’s meeting, Soriano said he saw great possibilities in Malaysia.“We would like to talk to all of the Malaysian football stakeholders to find ways to collaborate,” he was quoted as saying by the New Straits Times newspaper.ADVERTISEMENT MOST READ Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue CFG already owns or has stakes in New York City, Melbourne City, Japan’s Yokohama F Marinos, Atletico Torque, Girona and Sichuan Jiuniu, as well as star side Manchester City.City are flying high after winning the FA Cup last week, completing a domestic treble with the English league title and the League Cup.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsManchester City’s Spanish manager Pep Guardiola (L) takes part in a stage presentation following an open-top bus parade through Manchester, northern England on May 20, 2019, to celebrate winning the 2019 Premier League title, the FA Cup and English League Cup. (Photo by Paul ELLIS / AFP)“They are looking at the possibility of co-owning a Malaysian club,” Ahmad Shapawi Ismail, director-general of Malaysia’s national sports council, told AFP.The official, who was present at Thursday’s meeting, said he was “delighted and excited” at the news, adding: “We need (their) expertise.” Catholic schools seek legislated pay hike, toocenter_img Sports venues to be ready in time for SEA Games PLAY LIST 00:59Sports venues to be ready in time for SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games00:50Trending Articles02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss LATEST STORIES “We see Malaysia has an opportunity for football… the level of enthusiasm of the fans is obvious. The development of Malaysian football and the league in the last year with investment by the government shows that there’s great opportunity.”It is the latest Asian country being considered by CFG — in March, Soriano said the group wanted to invest in India.Football is popular in Malaysia but the country does not perform well on the international stage, and is currently ranked 168th in the world.Sports Related Videospowered by AdSparcRead Next DA eyes importing ‘galunggong’ anew Two-day strike in Bicol fails to cripple transport Don’t miss out on the latest news and information. After solid debut, Prince Ibeh determined to give more for NorthPort CEO of City Group, Ferran Soriano speaks during a session of the 13th edition of the Dubai International Sports Conference, at Madinat Jumeirah in Dubai on January 2, 2019. (Photo by Fabio FERRARI / La Presse / AFP) / Italy OUT – China OUTThe owners of Premier League champions Manchester City are eyeing a stake in a Malaysian team to add to their growing portfolio of clubs, a sports official said Friday.Ferran Soriano — chief executive of City Football Group (CFG), which is bankrolled by Sheikh Mansour of the Abu Dhabi royal family — raised the possibility when he met Sports Minister Syed Saddiq in Malaysia on Thursday.ADVERTISEMENTlast_img read more

10 months agoNeves proud playing with Moutinho at Wolves

first_imgAbout the authorPaul VegasShare the loveHave your say Neves proud playing with Moutinho at Wolvesby Paul Vegas10 months agoSend to a friendShare the loveRuben Neves admits he’s enjoying playing with Joao Moutinho in the Wolves midfield this season.It has been a thrill for Neves to partner his compatriot after growing up a fan and ball boy at Porto, where Moutinho starred.Neves told the Mirror: “It was really special when he signed here. When I was younger I saw Moutinho playing and he was very good.“He was a reference for me as a ball boy and now to play with him, it is unbelievable.”Swapping Champions League football for the English second tier may have seemed an unusual move but he had his reasons: “The Championship allows you to grow as a player. It is very competitive.” last_img read more

Celtic Or Maverick Rajon Rondo Remains A Mystery

The first blockbuster trade of the 2014-15 NBA season came late Thursday, when the Boston Celtics finally shipped Rajon Rondo, their perpetually on-the-trading-block star, to the Dallas Mavericks for a handful of players, picks and a trade exception.Others have broken down the pros and cons of the trade, but the deal also serves to spark discussion about Rondo himself, one of the most polarizing players in the league. In early November, when Grantland’s Kirk Goldsberry profiled the enigmatic point guard, he touched on the conundrum advanced stats face in measuring his performance. “Rondo’s value is difficult to quantify, in part because he doesn’t fit into our established taxonomy of NBA superstars,” Goldsberry wrote. “He amplifies the goodness around him, but he can’t create it.”The statistical arc of Rondo’s career bears this out. According to metrics ranging from Player Efficiency Rating (PER) to Win Shares and Statistical Plus/Minus (SPM), Rondo’s best seasons came in 2009 and 2010, when he was surrounded by three future Hall of Famers in Kevin Garnett, Paul Pierce and Ray Allen. In Goldsberry’s terms, Rondo amplified their goodness — or at least, he helped organize it — and his numbers received a sizable boost as well. In 2009, he ranked as the NBA’s 14th-best player by Win Shares and its 12th-best by Value Over Replacement Player.But since Rondo tore his ACL midway through the 2012-13 season and the Celtics broke up their “Big Three” for good, Rondo’s output has taken a nosedive. Stats such as a .461 true shooting percentage (TS%) might have been excused while returning from injury a year ago, but Rondo has continued to shoot the ball poorly (.422 TS%), turn it over frequently (on nearly 26 percent of his possessions) and score infrequently (he’s averaging 9.4 points per 36 minutes) this season. Abysmal numbers like those would typically warrant a benching, not a win-now return in a blockbuster trade.Then again, Rondo has never been a typical player. Along with the bad shooting and nonexistent scoring, he also provides his team with one of the game’s most prolific passers, its best rebounding point guard, a highly skilled thief and an elite defender. In other words, there’s precious little middle ground with Rondo; pick an area of the game, and he’s either one of the best or one of the worst in it.So, how do we weigh the positives of Rondo’s game against the negatives? The popular single-number metrics are all over the place. PER thinks he’s average so far this season; Win Shares per 48 minutes considers him substantially below average. Naturally, Wins Produced likes him for his rebounding prowess (and doesn’t care about his microscopic scoring output), while Box Plus/Minus (an SPM variant) pegs him as above-average but completely because of defense (he’s quite negative offensively). Box Plus/Minus jibes with what ESPN’s Real Plus/Minus (RPM) lists for Rondo this season, but last year RPM considered him good offensively and bad defensively (go figure).Dallas owner Mark Cuban has always had the Mavericks at the forefront of analytics among NBA teams, so it’s possible he’s found his own way to cut through the fog and divine Rondo’s true worth. But for the rest of us, the debate over Rondo is one of how best to measure a unique player. Advanced as they are, our best statistical formulas are trained on trends that emerge over the entire sample of NBA players. Rondo might just be the extreme case that causes our math to break down. read more

Trio of Buckeyes earn weekly Big Ten honors

Senior running back Carlos Hyde (34) breaks a tackle during a game against Northwestern Oct. 5 at Ryan Field. OSU won, 40-30.Credit: Shelby Lum / Photo editorThree members of the Ohio State football team claimed individual Big Ten player of the week honors for their performances in the Buckeyes’ 40-30 victory over then-No. 16 Northwestern.The three players who earned honors after the Saturday game were redshirt-junior cornerback Bradley Roby, senior running back Carlos Hyde and freshman defensive lineman Joey Bosa.Hyde was named co-offensive player of the week after he sliced through the Northwestern defense on his way to a career-high 168 rushing yards and three touchdowns on 26 carries. He also caught four passes for 38 yards. Hyde further collected 15 first downs — 12 on the ground and three through the air — and scored the go-ahead touchdown for the Buckeyes with just more than five minutes left.“We didn’t run anything crazy, we stuck to our basic runs and our O-line was having success in our blocks and I was having success in the reads. They were just making it easy for me,” Hyde said after the game.Roby earned special teams player of the week after recording seven tackles on the night, two of which came on special teams. He also blocked the second punt of his Buckeye career, recovering it in the Wildcat end zone for what was OSU’s only touchdown in the first half.“They didn’t block me,” Roby said about the punt block. “I thought they were going to try to block me, but they didn’t, so I just went to go get it.”Bosa had five tackles in the game and sacked Northwestern quarterbacks two times on his way to being named freshman of the week in the conference. He also scored his first career touchdown by recovering a fumble in the end zone on the game’s final play.“They couldn’t really block us throughout that game, so we wanted to bring some heat,” Bosa said.The conference honors mark the fourth week in a row that at least one Buckeye has made the list. Junior quarterback Braxton Miller and freshman punter Cameron Johnston were selected after the team’s win over Wisconsin Sept. 28, redshirt-senior quarterback Kenny Guiton received the nod after throwing for six touchdowns against Florida A&M Sept. 21 and also won it the week before along with junior linebacker Ryan Shazier after OSU beat California Sept. 14.The Buckeyes are off this week but are scheduled to return home to take on Iowa Oct. 19 at Ohio Stadium. read more

Bristol Rovers sign Bournemouth ace

first_imgAFC Bournemouth midfielder Sam Matthews has become Bristol Rovers second signing of the summer after he signed a contract with the club. A deal that will take effect from July 1.Manager Darrell Clarke was delighted to have Sam agree to the transfer, according to Gazette series he said:“Sam is a very talented young player whose progress I have monitored for a while now.“He has worked hard and, learnt a great deal, from his time at Bournemouth and, of course, during his loan spell at Eastleigh in the National League last season.“We had to compete with a number of other clubs for his signature and I am delighted that he has chosen to join us “His arrival will intensify competition for first team places at the club and I look forward to working with him.”AFC Bournemouth v Manchester City - Premier LeagueMatch Preview: Bournemouth vs Manchester City Boro Tanchev – August 24, 2019 English champions Manchester City travel to Bournemouth for their encounter of the third Premier League Matchday.Upon signing, Sam continued;“I was on loan at Eastleigh last season and played quite a lot of games in the National League and then had some interest from other clubs, Rovers being one of them.“I met with Darrell Clarke over the summer, had a chat and as things progressed it’s resulted in me signing today and I’m really happy to get it done.“He told about the club itself, the squad the he has here and told me there’s great spirit amongst the players.”last_img read more